Nanofibrous Scaffolds for Orderly Corneal Wound Healing
نویسندگان
چکیده
Statement of Purpose: Corneal blindness deprives 10 million people worldwide of their sight. Current treatments for corneal blindness mainly rely on implants that replace the injured tissue and have been clinically unsuccessful thus far. The goal of this project is to prevent corneal blindness by developing clinically-viable scaffolds that promote orderly corneal wound healing using biochemical and topological cues. Specifically, we have created a composite scaffold, comprised of oriented protein nanofibers embedded within a soft, degradable hydrogel matrix, reminiscent of the native cornea. We have studied our composite scaffold extensively in vitro using rabbit corneal fibroblasts, ex vivo using intact rabbit eyes and in vivo using a mouse and rabbit model.
منابع مشابه
Nanofibrous scaffolds in biomedical applications
Nanofibrous scaffolds are artificial extracellular matrices which provide natural environment for tissue formation. In comparison to other forms of scaffolds, the nanofibrous scaffolds promote cell adhesion, proliferation and differentiation more efficiently due to having high surface to volume ratio. Although scaffolds for tissue engineering have been fabricated by various techniques but elect...
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